Ontology highlight
ABSTRACT:
SUBMITTER: Jennemann R
PROVIDER: S-EPMC1194904 | biostudies-other | 2005 Aug
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20050818 35
Sialic acid-containing glycosphingolipids, i.e., gangliosides, constitute a major component of neuronal cells and are thought to be essential for brain function. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyzes the initial step of glycosphingolipid (GSL) biosynthesis. To gain insight into the role of GSLs in brain development and function, a cell-specific disruption of Ugcg was performed as indicated by the absence of virtually all glucosylceramide-based GSLs. Shortly after birth, mice ...[more]