Ontology highlight
ABSTRACT:
SUBMITTER: Schlenstedt G
PROVIDER: S-EPMC1326308 | biostudies-other | 1997 Oct
REPOSITORIES: biostudies-other
Schlenstedt G G Smirnova E E Deane R R Solsbacher J J Kutay U U Görlich D D Ponstingl H H Bischoff F R FR
The EMBO journal 19971001 20
Gsp1p, the essential yeast Ran homologue, is a key regulator of transport across the nuclear pore complex (NPC). We report the identification of Yrb4p, a novel Gsp1p binding protein. The 123 kDa protein was isolated from Saccharomyces cerevisiae cells and found to be related to importin-beta, the mediator of nuclear localization signal (NLS)-dependent import into the nucleus, and to Pse1p. Like importin-beta, Yrb4p and Pse1p specifically bind to Gsp1p-GTP, protecting it from GTP hydrolysis and n ...[more]