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A sigma28-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176.

ABSTRACT: A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.

SUBMITTER: Goon S 

PROVIDER: S-EPMC1346654 | biostudies-other | 2006 Jan

REPOSITORIES: biostudies-other

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A sigma28-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176.

Goon Scarlett S   Ewing Cheryl P CP   Lorenzo Maria M   Pattarini Dawn D   Majam Gary G   Guerry Patricia P  

Infection and immunity 20060101 1

A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure. ...[more]