Unknown

Dataset Information

0

Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.

ABSTRACT: We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P

SUBMITTER: Chapman K 

PROVIDER: S-EPMC1378087 | biostudies-other | 1999 Jul

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.

Chapman K K   Mustafa Z Z   Irven C C   Carr A J AJ   Clipsham K K   Smith A A   Chitnavis J J   Sinsheimer J S JS   Bloomfield V A VA   McCartney M M   Cox O O   Cardon L R LR   Sykes B B   Loughlin J J  

American journal of human genetics 19990701 1

We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P</=.05 were then taken through to the second stage, with an additional 184 families. This second stage confirmed evidence of linkage for m  ...[more]

Similar Datasets

Unknown Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.
| S-EPMC4067321 | biostudies-literature
Unknown Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus.
| S-EPMC2850168 | biostudies-literature
Unknown A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
| S-EPMC3354739 | biostudies-literature
Unknown A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search.
| S-EPMC378544 | biostudies-literature
Unknown Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.
| S-EPMC1181982 | biostudies-literature
Unknown Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.
| S-EPMC4562116 | biostudies-literature
Unknown Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12.
| S-EPMC481059 | biostudies-literature
Unknown Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.
| S-EPMC3615180 | biostudies-literature
Unknown A strabismus susceptibility locus on chromosome 7p.
| S-EPMC218750 | biostudies-literature
Unknown A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18.
| S-EPMC3746276 | biostudies-literature