Ontology highlight
ABSTRACT:
SUBMITTER: Stiff T
PROVIDER: S-EPMC1698893 | biostudies-other | 2006 Dec
REPOSITORIES: biostudies-other
The EMBO journal 20061123 24
The phosphatidyl inositol 3-kinase-like kinases (PIKKs), ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) regulate parallel damage response signalling pathways. ATM is reported to be activated by DNA double-strand breaks (DSBs), whereas ATR is recruited to single-stranded regions of DNA. Although the two pathways were considered to function independently, recent studies have demonstrated that ATM functions upstream of ATR following exposure to ionising radiation (IR) in S/G2. ...[more]