Ontology highlight
ABSTRACT:
SUBMITTER: Pirofski L
PROVIDER: S-EPMC173409 | biostudies-other | 1995 Aug
REPOSITORIES: biostudies-other
Infection and immunity 19950801 8
The Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan (GXM) has been conjugated to tetanus toxoid (GXM-TT) as an investigational vaccine. GXM-TT elicits antibodies that are protective in C. neoformans-infected mice. In an effort to characterize the fine specificity and molecular structure of human GXM-TT-elicited antibodies, we generated two GXM monoclonal antibodies (MAbs) from peripheral blood lymphocytes of a volunteer GXM-TT recipient and studied serum GXM antibody idiotype ...[more]