Unknown

Dataset Information

0

Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist.


ABSTRACT: A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL.

SUBMITTER: Matsuda K 

PROVIDER: S-EPMC1760657 | biostudies-other | 1999 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC10482695 | biostudies-literature
| S-EPMC3441550 | biostudies-literature
| S-EPMC3963132 | biostudies-literature
| S-EPMC8983459 | biostudies-literature
| S-EPMC3411353 | biostudies-literature
| S-EPMC8086144 | biostudies-literature
| S-EPMC9173765 | biostudies-literature
2022-05-05 | GSE202335 | GEO
| S-EPMC5524711 | biostudies-literature
| S-EPMC9641778 | biostudies-literature