Ontology highlight
ABSTRACT:
SUBMITTER: Cheng G
PROVIDER: S-EPMC1885623 | biostudies-other | 2007 May
REPOSITORIES: biostudies-other
Cheng Guofeng G Zhong Jin J Chung Josan J Chisari Francis V FV
Proceedings of the National Academy of Sciences of the United States of America 20070515 21
Virus infection triggers IFN immune defenses in infected cells in part through viral nucleic acid interactions, but the pathways by which dsDNA and DNA viruses trigger innate defenses are only partially understood. Here we present evidence that both retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling protein (MAVS) are required for dsDNA-induced IFN-beta promoter activation in a human hepatoma cell line (Huh-7), and that activation is efficiently blocked by the hepatitis C ...[more]