Dataset Information
A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens.
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ABSTRACT:
SUBMITTER: Hara O
PROVIDER: S-EPMC206334 | biostudies-other | 1992 Aug
REPOSITORIES: biostudies-other
Publications
A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens.
Journal of bacteriology 19920801 15
The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene. ...[more]