Ontology highlight
ABSTRACT:
SUBMITTER: Shawar SM
PROVIDER: S-EPMC2118972 | biostudies-other | 1991 Oct
REPOSITORIES: biostudies-other
Shawar S M SM Vyas J M JM Rodgers J R JR Cook R G RG Rich R R RR
The Journal of experimental medicine 19911001 4
The physiological functions of the mouse telomeric major histocompatibility complex (MHC) class I molecules, including Hmt, are unknown. Hmt presents a polymorphic, N-formylated peptide encoded by the mitochondrial gene ND1 forming the cell surface maternally transmitted antigen (Mta). Because the N-formyl moiety is required for Hmt binding, we proposed that Hmt may function generally in presentation of N-formylated antigens. This hypothesis was validated by a competitive binding assay, demonstr ...[more]