Ontology highlight
ABSTRACT:
SUBMITTER: Roulier EM
PROVIDER: S-EPMC2289344 | biostudies-other | 1992 Feb
REPOSITORIES: biostudies-other
Roulier E M EM Fyrberg C C Fyrberg E E
The Journal of cell biology 19920201 4
We have investigated accumulation of alpha-actinin, the principal cross-linker of actin filaments, in four Drosophila fliA mutants. A single gene is variably spliced to generate one nonmuscle and two muscle isoforms whose primary sequence differences are confined to a peptide spanning the actin binding domain and first central repeat. In fliA3 the synthesis of an adult muscle-specific isoform is blocked in flight and leg muscles, while in fliA4 the synthesis of nonmuscle and both muscle-specific ...[more]