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The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway.

ABSTRACT: The vestibular system is a major pathway to nausea and vomiting, and the vestibuloocular reflex (VOR) is a central component; its function can be studied using the vestibular autorotation test (VAT). We hypothesize that women with hyperemesis gravidarum (HG) may have VOR abnormalities.Women with HG were compared with women without HG using the VAT. Horizontal and vertical VOR gains and phases were evaluated at 3 frequency ranges: low (2.0 to 3.5 Hz), medium (greater than 3.5 to 5.0 Hz), and high (greater than 5.0 to 6.0 Hz) during pregnancy and postpartum.Twenty women with HG and 48 unaffected women were evaluated in early pregnancy. Women with HG had higher horizontal gains at all 3 frequency ranges. Horizontal phase differences were also observed at medium frequencies. No VAT differences were noted postpartum.Women experiencing HG had a higher mean VOR horizontal gain and lower horizontal phase when compared with unaffected women.

SUBMITTER: Goodwin TM 

PROVIDER: S-EPMC2577839 | biostudies-other | 2008 Oct

REPOSITORIES: biostudies-other

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The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway.

Goodwin Thomas Murphy TM   Nwankwo Odinaka A OA   O'Leary Linda Davis LD   O'Leary Dennis D   Romero Roberto R   Korst Lisa M LM  

American journal of obstetrics and gynecology 20081001 4

<h4>Objective</h4>The vestibular system is a major pathway to nausea and vomiting, and the vestibuloocular reflex (VOR) is a central component; its function can be studied using the vestibular autorotation test (VAT). We hypothesize that women with hyperemesis gravidarum (HG) may have VOR abnormalities.<h4>Study design</h4>Women with HG were compared with women without HG using the VAT. Horizontal and vertical VOR gains and phases were evaluated at 3 frequency ranges: low (2.0 to 3.5 Hz), medium  ...[more]