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The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.

ABSTRACT: Invariant natural killer T cells (iNKT cells) have an innate immunity-like rapidity of response and the ability to modulate the effector functions of other cells. We show here that iNKT cells specifically expressed the BTB-zinc finger transcriptional regulator PLZF. In the absence of PLZF, iNKT cells developed, but they lacked many features of innate T cells. PLZF-deficient iNKT cells accumulated in lymph nodes rather than in the liver, did not express NK markers and did not have the characteristic activated phenotype. PLZF-deficient iNKT cells failed to secrete large amounts of interleukin 4 and interferon-gamma after activation; however, some cells produced either interleukin 4 or interferon-gamma but not both. PLZF, therefore, is an iNKT cell-specific transcription factor that is necessary for full functionality.

SUBMITTER: Kovalovsky D 

PROVIDER: S-EPMC2662733 | biostudies-other | 2008 Sep

REPOSITORIES: biostudies-other

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The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.

Kovalovsky Damian D   Uche Olisambu U OU   Eladad Sonia S   Hobbs Robin M RM   Yi Woelsung W   Alonzo Eric E   Chua Kevin K   Eidson Maggie M   Kim Hye-Jung HJ   Im Jin S JS   Pandolfi Pier Paolo PP   Sant'Angelo Derek B DB  

Nature immunology 20080727 9

Invariant natural killer T cells (iNKT cells) have an innate immunity-like rapidity of response and the ability to modulate the effector functions of other cells. We show here that iNKT cells specifically expressed the BTB-zinc finger transcriptional regulator PLZF. In the absence of PLZF, iNKT cells developed, but they lacked many features of innate T cells. PLZF-deficient iNKT cells accumulated in lymph nodes rather than in the liver, did not express NK markers and did not have the characteris  ...[more]

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