Ontology highlight
ABSTRACT:
SUBMITTER: Yang YT
PROVIDER: S-EPMC2685444 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Yang Ya-Ting YT Balch Curt C Kulp Samuel K SK Mand Michael R MR Nephew Kenneth P KP Chen Ching-Shih CS
Neoplasia (New York, N.Y.) 20090601 6
Histone deacetylase inhibitors (HDACIs) are a class of antineoplastic agents previously demonstrating preclinical chemosensitizing activity against drug-resistant cancer cells and mouse xenografts. However, whereas clinical studies have shown efficacy against human hematologic malignancies, solid tumor trials have proved disappointing. We previously developed a novel HDACI, "OSU-HDAC42," and herein examine its activity against ovarian cancer cell lines and xenografts. OSU-HDAC42, (i) unlike most ...[more]