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Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line.

ABSTRACT: Respiratory syncytial virus (RSV) infection involves complex virus-host interplay. In this study, we analyzed gene expression in RSV-infected BEAS-2B cells to discover novel signaling pathways and biomarkers. We hybridized RNAs from RSV- or vehicle-treated BEAS-2B to Affymetrix HU133 plus 2.0 microarrays (n = 4). At 4 and 24 h post-infection, 277 and 900 genes (RSV/control ratio >/=2.0 or

SUBMITTER: Huang YC 

PROVIDER: S-EPMC2694865 | biostudies-other | 2008 Dec

REPOSITORIES: biostudies-other

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Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line.

Huang Yuh-Chin T YC   Li Zhuowei Z   Hyseni Xhevahire X   Schmitt Michael M   Devlin Robert B RB   Karoly Edward D ED   Soukup Joleen M JM  

Genomic medicine 20081201 3-4

Respiratory syncytial virus (RSV) infection involves complex virus-host interplay. In this study, we analyzed gene expression in RSV-infected BEAS-2B cells to discover novel signaling pathways and biomarkers. We hybridized RNAs from RSV- or vehicle-treated BEAS-2B to Affymetrix HU133 plus 2.0 microarrays (n = 4). At 4 and 24 h post-infection, 277 and 900 genes (RSV/control ratio >/=2.0 or </=0.5), and 1 and 12 pathways respectively were significantly altered. Twenty-three and 92 genes at 4 and 2  ...[more]

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