Ontology highlight
ABSTRACT:
SUBMITTER: Guo J
PROVIDER: S-EPMC2772104 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Cell 20090910 6
The eukaryotic circadian oscillators consist of autoregulatory negative feedback loops. However, little is known about the role of posttranscriptional regulation of RNA in circadian oscillators. In the Neurospora circadian negative feedback loop, FRQ and FRH form the FFC complex that represses frq transcription. Here, we show that FFC also binds frq RNA and interacts with the exosome to regulate frq RNA decay. Consequently, frq RNA is robustly rhythmic as it is more stable when FRQ levels are lo ...[more]