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The RESA-2 gene of Plasmodium falciparum is transcribed in several independent isolates.

ABSTRACT: The relevance of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum as a malaria vaccine candidate has been questioned of late because RESA-deficient parasites have been found to multiply normally in culture or in monkeys. The RESA-2 gene was recently described as a pseudogene highly homologous to RESA. In this report, we demonstrate that RESA-2 is not a pseudogene, because we were able to detect RESA-2 transcripts in asexual blood stages of multiple isolates by using polymerase chain reaction on reverse-transcribed mRNA. Transcription of RESA-2 was observed whether or not the isolates studied expressed the RESA protein.

SUBMITTER: Vazeux G 

PROVIDER: S-EPMC281181 | biostudies-other | 1993 Oct

REPOSITORIES: biostudies-other

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The RESA-2 gene of Plasmodium falciparum is transcribed in several independent isolates.

Vazeux G G   Le Scanf C C   Fandeur T T  

Infection and immunity 19931001 10

The relevance of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum as a malaria vaccine candidate has been questioned of late because RESA-deficient parasites have been found to multiply normally in culture or in monkeys. The RESA-2 gene was recently described as a pseudogene highly homologous to RESA. In this report, we demonstrate that RESA-2 is not a pseudogene, because we were able to detect RESA-2 transcripts in asexual blood stages of multiple isolates by using  ...[more]