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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.

ABSTRACT: The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.

SUBMITTER: Ahmadiyeh N 

PROVIDER: S-EPMC2906844 | biostudies-other | 2010 May

REPOSITORIES: biostudies-other

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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.

Ahmadiyeh Nasim N   Pomerantz Mark M MM   Grisanzio Chiara C   Herman Paula P   Jia Li L   Almendro Vanessa V   He Housheng Hansen HH   Brown Myles M   Liu X Shirley XS   Davis Matt M   Caswell Jennifer L JL   Beckwith Christine A CA   Hills Adam A   Macconaill Laura L   Coetzee Gerhard A GA   Regan Meredith M MM   Freedman Matthew L ML  

Proceedings of the National Academy of Sciences of the United States of America 20100507 21

The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci oper  ...[more]

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