Ontology highlight
ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC2941340 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
Shi Yun Y Suh Young Ho YH Milstein Aaron D AD Isozaki Kaname K Schmid Sabine M SM Roche Katherine W KW Nicoll Roger A RA
Proceedings of the National Academy of Sciences of the United States of America 20100830 37
Glutamate receptors of the AMPA subtype (AMPARs) mediate fast synaptic transmission in the brain. These ionotropic receptors rely on auxiliary subunits known as transmembrane AMPAR regulatory proteins (TARPs) for both trafficking and gating. Recently, a second family of AMPAR binding proteins, referred to as cornichons, were identified and also proposed to function as auxiliary subunits. Cornichons are transmembrane proteins that modulate AMPAR function in expression systems much like TARPs. In ...[more]