Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating.

ABSTRACT: In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures.

SUBMITTER: Caglayan H 

PROVIDER: S-EPMC2945734 | biostudies-other | 2010 Aug

REPOSITORIES: biostudies-other