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6-Fluoro-4-oxochroman-2-carboxylic acid.

ABSTRACT: The title compound, C(10)H(7)FO(4), is an inter-mediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione. The di-hydro-pyran-one ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the mol-ecules are linked into zigzag chains along [100] by O-H?O hydrogen bonds and C-H?? inter-actions involving the benzene ring.

SUBMITTER: Chen P 

PROVIDER: S-EPMC2979877 | biostudies-other | 2010

REPOSITORIES: biostudies-other

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6-Fluoro-4-oxochroman-2-carboxylic acid.

Chen Pei P   Qian Shan S   Shi Zhe-Qin ZQ   Wu Yong Y  

Acta crystallographica. Section E, Structure reports online 20100109 Pt 2

The title compound, C(10)H(7)FO(4), is an inter-mediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione. The di-hydro-pyran-one ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the mol-ecules are linked into zigzag chains along [100] by O-H⋯O hydrogen bonds and C-H⋯π inter-actions involving the benzene ring. ...[more]