Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC2991533 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Biochemical and biophysical research communications 20101028 3
The human secretory leukocyte protease inhibitor (SLPI) is an 11.7 kD cysteine-rich protein that has been shown to possess anti-protease, anti-inflammatory, and antimicrobial properties. By using a Pichia pastoris strain that overproduces protein disulfide isomerase (PDI), we obtained greater than fivefold higher levels of SLPI than in strains expressing normal levels of PDI and containing multiple copies of the SLPI gene. Elevated levels of PDI also enhanced the specific activity of the secrete ...[more]