Ras/MAPK signaling from endomembranes.

ABSTRACT: Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output.

SUBMITTER: Fehrenbacher N 

PROVIDER: S-EPMC3003591 | biostudies-other | 2009 Aug

REPOSITORIES: biostudies-other