Ontology highlight
ABSTRACT:
SUBMITTER: Gill SR
PROVIDER: S-EPMC301080 | biostudies-other | 1994 Jun
REPOSITORIES: biostudies-other
Gill S R SR Cleveland D W DW Schroer T A TA
Molecular biology of the cell 19940601 6
Cytoplasmic dynein is a minus-end-directed, microtubule-dependent motor composed of two heavy chains (approximately 530 kDa), three intermediate chains (approximately 74 kDa), and a family of approximately 52-61 kDa light chains. Although the approximately 530 kDa subunit contains the motor and microtubule binding domains of the complex, the functions of the smaller subunits are not known. Using two-dimensional gel electrophoresis and proteolytic mapping, we show here that the light chains are c ...[more]