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Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.

ABSTRACT: N,N-dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.

SUBMITTER: Hsu BB 

PROVIDER: S-EPMC3017173 | biostudies-other | 2011 Jan

REPOSITORIES: biostudies-other

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Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.

Hsu Bryan B BB   Yinn Wong Sze S   Hammond Paula T PT   Chen Jianzhu J   Klibanov Alexander M AM  

Proceedings of the National Academy of Sciences of the United States of America 20101220 1

N,N-dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural  ...[more]