Ontology highlight
ABSTRACT:
SUBMITTER: del Camino D
PROVIDER: S-EPMC3021322 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
The Journal of neuroscience : the official journal of the Society for Neuroscience 20101101 45
TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial. Here, we demonstrate that mild cooling markedly increases agonist-evoked rat TRPA1 currents. In the absence of an agonist, even noxious cold only increases current amplitude slightly. These results suggest that TRPA1 is a key mediator of cold hypersensitivity in pathol ...[more]