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Shuttle mutagenesis of Legionella pneumophila: identification of a gene associated with host cell cytopathicity.

ABSTRACT: We performed shuttle mutagenesis of Legionella pneumophila. Mutants were screened for reduced cellular infectivity. Approximately 10% of the mutants had decreased cytopathicity. The DNA sequence of one locus was determined; the inferred amino acid sequence revealed homology with transport proteins including Escherichia coli TolC, Bordetella pertussis CyaE, and Alcaligenes eutrophus CzcC and CnrC.

SUBMITTER: Arroyo J 

PROVIDER: S-EPMC303072 | biostudies-other | 1994 Sep

REPOSITORIES: biostudies-other

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Shuttle mutagenesis of Legionella pneumophila: identification of a gene associated with host cell cytopathicity.

Arroyo J J   Hurley M C MC   Wolf M M   McClain M S MS   Eisenstein B I BI   Engleberg N C NC  

Infection and immunity 19940901 9

We performed shuttle mutagenesis of Legionella pneumophila. Mutants were screened for reduced cellular infectivity. Approximately 10% of the mutants had decreased cytopathicity. The DNA sequence of one locus was determined; the inferred amino acid sequence revealed homology with transport proteins including Escherichia coli TolC, Bordetella pertussis CyaE, and Alcaligenes eutrophus CzcC and CnrC. ...[more]