Ontology highlight
ABSTRACT:
SUBMITTER: Bas A
PROVIDER: S-EPMC3060244 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20110228 11
Although local regulation of T-cell responses by epithelial cells is increasingly viewed as important, few molecules mediating such regulation have been identified. Skint1, a recently identified member of the Ig-supergene family expressed by thymic epithelial cells and keratinocytes, specifies the murine epidermal intraepithelial lymphocyte (IEL) repertoire. Investigating whether Skint1-related molecules might regulate IEL in other compartments, this study focuses on buytrophilin-like 1 (Btnl1), ...[more]