Ontology highlight
ABSTRACT:
SUBMITTER: Su J
PROVIDER: S-EPMC3064800 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Su Jie J Baigude Huricha H McCarroll Joshua J Rana Tariq M TM
Nucleic acids research 20110106 6
MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate post-transcriptional gene expression and are important in many biological processes. Disease-associated miRNAs have been shown to become potential targets for therapeutic intervention. Functions of miRNAs can be inhibited by using antisense oligonucleotides, called anti-miRs, complimentary to the miRNA sequences. Here, we show that systemic delivery of a chemically stabilized anti-miR-122 complexed with interfering nanoparticl ...[more]