Ontology highlight
ABSTRACT:
SUBMITTER: Shahzad MM
PROVIDER: S-EPMC3071079 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Shahzad Mian M K MM Mangala Lingegowda S LS Han Hee Dong HD Lu Chunhua C Bottsford-Miller Justin J Nishimura Masato M Mora Edna M EM Lee Jeong-Won JW Stone Rebecca L RL Pecot Chad V CV Thanapprapasr Duangmani D Roh Ju-Won JW Gaur Puja P Nair Maya P MP Park Yun-Yong YY Sabnis Nirupama N Deavers Michael T MT Lee Ju-Seog JS Ellis Lee M LM Lopez-Berestein Gabriel G McConathy Walter J WJ Prokai Laszlo L Lacko Andras G AG Sood Anil K AK
Neoplasia (New York, N.Y.) 20110401 4
RNA interference holds tremendous potential as a therapeutic approach, especially in the treatment of malignant tumors. However, efficient and biocompatible delivery methods are needed for systemic delivery of small interfering RNA (siRNA). To maintain a high level of growth, tumor cells scavenge high-density lipoprotein (HDL) particles by overexpressing its receptor: scavenger receptor type B1 (SR-B1). In this study, we exploited this cellular characteristic to achieve efficient siRNA delivery ...[more]