Ontology highlight
ABSTRACT:
SUBMITTER: Boulos N
PROVIDER: S-EPMC3072880 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Boulos Nidal N Mulder Heather L HL Calabrese Christopher R CR Morrison Jeffrey B JB Rehg Jerold E JE Relling Mary V MV Sherr Charles J CJ Williams Richard T RT
Blood 20110124 13
The introduction of cultured p185(BCR-ABL)-expressing (p185+) Arf (-/-) pre-B cells into healthy syngeneic mice induces aggressive acute lymphoblastic leukemia (ALL) that genetically and phenotypically mimics the human disease. We adapted this high-throughput Philadelphia chromosome-positive (Ph(+)) ALL animal model for in vivo luminescent imaging to investigate disease progression, targeted therapeutic response, and ALL relapse in living mice. Mice bearing high leukemic burdens (simulating huma ...[more]