Michaelis-Menten speeds up tau-leaping under a wide range of conditions.

ABSTRACT: This paper examines the benefits of Michaelis-Menten model reduction techniques in stochastic tau-leaping simulations. Results show that although the conditions for the validity of the reductions for tau-leaping remain the same as those for the stochastic simulation algorithm (SSA), the reductions result in a substantial speed-up for tau-leaping under a different range of conditions than they do for SSA. The reason of this discrepancy is that the time steps for SSA and for tau-leaping are determined by different properties of system dynamics.

SUBMITTER: Wu S 

PROVIDER: S-EPMC3087420 | biostudies-other | 2011 Apr

REPOSITORIES: biostudies-other