Ontology highlight
ABSTRACT:
SUBMITTER: Guan JS
PROVIDER: S-EPMC3184170 | biostudies-other | 2011
REPOSITORIES: biostudies-other
PloS one 20110930 9
Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of synaptic plasticity in cultured neurons. Surprisingly, we found that Cdk5 loss of function in hippocampal circuits results in severe impairments in memory formation and retrieval. Moreover, Cdk5 loss ...[more]