Ontology highlight
ABSTRACT:
SUBMITTER: Morizane S
PROVIDER: S-EPMC3220926 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
The Journal of investigative dermatology 20110818 1
Here we show that keratinocytes in psoriatic lesional skin express increased Toll-like receptor (TLR) 9 that similarly localizes with elevated expression of the cathelicidin antimicrobial peptide LL-37. In culture, normal human keratinocytes exposed to LL-37 increased TLR9 expression. Furthermore, when keratinocytes were exposed to LL-37 and subsequently treated with TLR9 ligands, such as CpG or genomic DNA, they greatly increased production of type I IFNs. This response mimicked observations in ...[more]