Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.

ABSTRACT: Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.

SUBMITTER: Dehay B 

PROVIDER: S-EPMC3275921 | biostudies-other | 2012

REPOSITORIES: biostudies-other