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Signal control through Raf: in sickness and in health.


ABSTRACT: The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.

SUBMITTER: Osborne JK 

PROVIDER: S-EPMC3351917 | biostudies-other | 2012 Jan

REPOSITORIES: biostudies-other

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