Ontology highlight
ABSTRACT:
SUBMITTER: Alimova I
PROVIDER: S-EPMC3375399 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
International journal of cancer 20120730 8
Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription. EZH2 enhances cancer-cell proliferation and regulates stem cell maintenance and differentiation. Here, we demonstrate that EZH2 is highly expressed in medulloblastoma, a highly malignant brain tumor of childhood, and this altered expression is correlated with genomic gain of chromosome 7 in a subset of medullob ...[more]