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MiR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.

ABSTRACT: More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA breaks and promoted granulosa cell apoptosis by targeting the ataxia telangiectasia mutated gene directly in vitro.

SUBMITTER: Lin F 

PROVIDER: S-EPMC3380909 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.

Lin Fei F   Li Ran R   Pan Zeng Xiang ZX   Zhou Bo B   Yu De Bing DB   Wang Xu Guang XG   Ma Xue Shan XS   Han Jing J   Shen Ming M   Liu Hong Lin HL  

PloS one 20120621 6

More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA  ...[more]

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