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Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.

ABSTRACT: Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated chromosomes. The latter requires Eso1 only in the presence of Wapl, indicating that cohesin stabilization relies on Eso1 only to neutralize the anti-establishment activity. We suggest that Eso1 requires Pds5 to counteract anti-establishment. This allows both cohesion establishment and Pds5-dependent stable cohesin binding to chromosomes.

SUBMITTER: Vaur S 

PROVIDER: S-EPMC3388792 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other

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Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.

Vaur Sabine S   Feytout Amélie A   Vazquez Stéphanie S   Javerzat Jean-Paul JP  

EMBO reports 20120629 7

Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated chromosomes. The latter requires Eso1 only in the presence of Wapl, indicating that cohesin stabilizat  ...[more]