Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC3484450 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
The Journal of clinical investigation 20121008 11
Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. Here, we have described a cleavage product of the COL6α3 chain, endotrophin (ETP), which serves as the major mediator of the COL6-mediated tumor effects. ETP augmented fibrosis, angiogenesis, and inflammation throu ...[more]