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Molecular markers associated with outcome and metastasis in human pancreatic cancer.

ABSTRACT: BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis are not well understood. METHODS: We performed microarray analyses on whole-tumour samples of 2 human PDAC subpopulations with similar clinicopathological features, but extremely distinct survival rates after potentially curative surgery, i.e. good outcome (OS and DFS?>?50?months, n?=?7) versus bad outcome (OS?

SUBMITTER: Van den Broeck A 

PROVIDER: S-EPMC3511800 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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Molecular markers associated with outcome and metastasis in human pancreatic cancer.

Van den Broeck Anke A   Vankelecom Hugo H   Van Eijsden Rudy R   Govaere Olivier O   Topal Baki B  

Journal of experimental & clinical cancer research : CR 20120827

<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis are not well understood.<h4>Methods</h4>We performed microarray analyses on whole-tumour samples of 2 human PDAC subpopulations with similar clinicopathological features, but extre  ...[more]