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Effects of familial mutations on the monomer structure of A???.

ABSTRACT: Amyloid beta (A?) peptide plays an important role in Alzheimer's disease. A number of mutations in the A? sequence lead to familial Alzheimer's disease, congophilic amyloid angiopathy, or hereditary cerebral hemorrhage with amyloid. Using molecular dynamics simulations of ?200 ?s for each system, we characterize and contrast the consequences of four pathogenic mutations (Italian, Dutch, Arctic, and Iowa) for the structural ensemble of the A? monomer. The four familial mutations are found to have distinct consequences for the monomer structure.

SUBMITTER: Lin YS 

PROVIDER: S-EPMC3525840 | biostudies-other | 2012 Dec

REPOSITORIES: biostudies-other

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Effects of familial mutations on the monomer structure of Aβ₄₂.

Lin Yu-Shan YS   Pande Vijay S VS  

Biophysical journal 20121218 12

Amyloid beta (Aβ) peptide plays an important role in Alzheimer's disease. A number of mutations in the Aβ sequence lead to familial Alzheimer's disease, congophilic amyloid angiopathy, or hereditary cerebral hemorrhage with amyloid. Using molecular dynamics simulations of ∼200 μs for each system, we characterize and contrast the consequences of four pathogenic mutations (Italian, Dutch, Arctic, and Iowa) for the structural ensemble of the Aβ monomer. The four familial mutations are found to have  ...[more]