Ontology highlight
ABSTRACT:
SUBMITTER: Bivas-Benita M
PROVIDER: S-EPMC3534169 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Mucosal immunology 20120718 1
Vaccination strategies for protection against a number of respiratory pathogens must induce T-cell populations in both the pulmonary airways and peripheral lymphoid organs. In this study, we show that pulmonary immunization using plasmid DNA formulated with the polymer polyethyleneimine (PEI-DNA) induced antigen-specific CD8(+) T cells in the airways that persisted long after antigen local clearance. The persistence of the cells was not mediated by local lymphocyte proliferation or persistent an ...[more]