Ontology highlight
ABSTRACT:
SUBMITTER: Kopp JL
PROVIDER: S-EPMC3568632 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Cancer cell 20121129 6
Tumors are largely classified by histologic appearance, yet morphologic features do not necessarily predict cellular origin. To determine the origin of pancreatic ductal adenocarcinoma (PDA), we labeled and traced pancreatic cell populations after induction of a PDA-initiating Kras mutation. Our studies reveal that ductal and stem-like centroacinar cells are surprisingly refractory to oncogenic transformation, whereas acinar cells readily form PDA precursor lesions with ductal features. We show ...[more]