Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC3624799 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Bioinformatics (Oxford, England) 20130214 8
<h4>Summary</h4>We propose a targeted re-sequencing simulator Wessim that generates synthetic exome sequencing reads from a given sample genome. Wessim emulates conventional exome capture technologies, including Agilent's SureSelect and NimbleGen's SeqCap, to generate DNA fragments from genomic target regions. The target regions can be either specified by genomic coordinates or inferred from in silico probe hybridization. Coupled with existing next-generation sequencing simulators, Wessim genera ...[more]