Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.

ABSTRACT: During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosome consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (approximately 1-kb-long) telomeric sequence.

SUBMITTER: Pace T 

PROVIDER: S-EPMC362954 | biostudies-other | 1990 Dec

REPOSITORIES: biostudies-other