Unknown

Dataset Information

0

Genetic evaluation of the performance of malaria parasite clearance rate metrics.

ABSTRACT: Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols.

SUBMITTER: Nkhoma SC 

PROVIDER: S-EPMC3685230 | biostudies-other | 2013 Jul

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Genetic evaluation of the performance of malaria parasite clearance rate metrics.

Nkhoma Standwell C SC   Stepniewska Kasia K   Nair Shalini S   Phyo Aung Pyae AP   McGready Rose R   Nosten François F   Anderson Tim J C TJ  

The Journal of infectious diseases 20130416 2

Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 5  ...[more]