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Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.


ABSTRACT: Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1-mediated angiogenesis or lectin, galactoside-binding, soluble, 1 deficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.

SUBMITTER: Freitag N 

PROVIDER: S-EPMC3710834 | biostudies-other | 2013 Jul

REPOSITORIES: biostudies-other

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Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.

Freitag Nancy N   Tirado-González Irene I   Barrientos Gabriela G   Herse Florian F   Thijssen Victor L J L VL   Weedon-Fekjær Susanne M SM   Schulz Herbert H   Wallukat Gerd G   Klapp Burghard F BF   Nevers Tania T   Sharma Surendra S   Staff Anne Cathrine AC   Dechend Ralf R   Blois Sandra M SM  

Proceedings of the National Academy of Sciences of the United States of America 20130624 28


Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits pro  ...[more]

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