Ontology highlight
ABSTRACT:
SUBMITTER: Freitag N
PROVIDER: S-EPMC3710834 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20130624 28
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits pro ...[more]