Ontology highlight
ABSTRACT:
SUBMITTER: Werner ME
PROVIDER: S-EPMC3725518 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
American journal of physiology. Cell physiology 20130320 1
Mutations in inversin cause nephronophthisis type II, an autosomal recessive form of polycystic kidney disease associated with situs inversus, dilatation, and kidney cyst formation. Since cyst formation may represent a planar polarity defect, we investigated whether inversin plays a role in cell division. In developing nephrons from inv-/- mouse embryos we observed heterogeneity of nuclear size, increased cell membrane perimeters, cells with double cilia, and increased frequency of binuclear cel ...[more]