Dataset Information
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.
Ontology highlight
ABSTRACT:
SUBMITTER: Gratz SJ
PROVIDER: S-EPMC3730909 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Publications
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.
Genetics 20130524 4
We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila genome and report that Cas9-mediated genomic modifications are efficiently transmitted through the germline. This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila. ...[more]